Chi Ching Mak Selected Research

4- chloro- 3- (5- methyl- 3- ((4- (2- pyrrolidin- 1- ylethoxy)phenyl)amino)- 1,2,4- benzotriazin- 7- yl)phenol

1/2009	Development of novel benzotriazines for drug discovery.
3/2008	Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration.

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Chi Ching Mak Research Topics

Disease

3	Neoplasms (Cancer) 01/2020 - 02/2007
2	Macular Degeneration (Age-Related Maculopathy) 01/2009 - 03/2008
1	Polycythemia Vera 04/2008
1	Edema (Dropsy) 03/2008
1	Choroidal Neovascularization 03/2008
1	Philadelphia Chromosome 01/2008
1	Myocardial Ischemia (Ischemic Heart Diseases) 03/2006
1	Ischemia 03/2006

Drug/Important Bio-Agent (IBA)

2	4- chloro- 3- (5- methyl- 3- ((4- (2- pyrrolidin- 1- ylethoxy)phenyl)amino)- 1,2,4- benzotriazin- 7- yl)phenolIBA 01/2009 - 03/2008
1	CateninsIBA 01/2020
1	Phosphotransferases (Kinase)IBA 01/2020
1	Tirapazamine (SR 4233)IBA 01/2009
1	fedratinibIBA 04/2008
1	Benzoates (Benzoate)IBA 03/2008
1	ProdrugsIBA 03/2008
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2008
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2008
1	src-Family KinasesIBA 02/2007
1	AminesIBA 02/2007
1	methyl 5- (N- (4- (1,1,1,3,3,3- hexafluoro- 2- hydroxypropan- 2- yl)phenyl)morpholine- 4- carboxamido)pentanoateIBA 03/2006

Therapy/Procedure

1	Lasers (Laser) 03/2008